| Player | Team | G | GS | Att | Yard | TD | Target | Rec | Yard | TD | WCOFF | NFFC | Standard Scoring | PPR | FFTOC |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 100. Mike Karney | NO | 12 | 8 | 8 | 10 | 2 | 12 | 9 | 18 | 0 | 23.8 | 19.3 | 14.8 | 23.8 | 23.8 |
| Aaron Stecker | NO | 6 | 0 | 8 | 43 | 0 | 12 | 9 | 52 | 1 | 24.5 | 20 | 15.5 | 24.5 | 24.5 |
| Adrian Peterson | MIN | 16 | 15 | 364 | 1757 | 10 | 39 | 21 | 125 | 0 | 269.2 | 258.7 | 248.2 | 269.2 | 269.2 |
| Ahmad Bradshaw | NYG | 15 | 0 | 67 | 355 | 1 | 6 | 5 | 42 | 1 | 56.7 | 54.2 | 51.7 | 56.7 | 56.7 |
| Ahman Green | HOU | 8 | 1 | 74 | 294 | 3 | 14 | 11 | 32 | 0 | 61.6 | 56.1 | 50.6 | 61.6 | 61.6 |
| Ahmard Hall | TEN | 16 | 11 | 8 | 21 | 0 | 18 | 13 | 138 | 2 | 40.9 | 34.4 | 27.9 | 40.9 | 40.9 |
| Andre Hall | DEN | 8 | 0 | 35 | 144 | 0 | 3 | 3 | 25 | 0 | 19.9 | 18.4 | 16.9 | 19.9 | 19.9 |
| Antonio Pittman | STL | 11 | 4 | 76 | 283 | 0 | 26 | 18 | 129 | 0 | 59.2 | 50.2 | 41.2 | 59.2 | 59.2 |
| B.J. Askew | TB | 10 | 5 | 7 | 14 | 2 | 18 | 13 | 66 | 0 | 33 | 26.5 | 20 | 33 | 33 |
| BenJarvus Green-Ellis | NE | 9 | 3 | 74 | 275 | 5 | 6 | 3 | 37 | 0 | 64.2 | 62.7 | 61.2 | 64.2 | 64.2 |
| Brandon Jackson | GB | 13 | 0 | 45 | 248 | 1 | 38 | 30 | 185 | 0 | 79.3 | 64.3 | 49.3 | 79.3 | 79.3 |
| Brandon Jacobs | NYG | 13 | 13 | 219 | 1089 | 15 | 12 | 6 | 36 | 0 | 208.5 | 205.5 | 202.5 | 208.5 | 208.5 |
| Brian Westbrook | PHI | 14 | 14 | 233 | 936 | 9 | 73 | 54 | 402 | 5 | 271.8 | 244.8 | 217.8 | 271.8 | 271.8 |
| Carnell Cadillac Williams | TB | 6 | 1 | 63 | 233 | 4 | 7 | 7 | 43 | 0 | 58.6 | 55.1 | 51.6 | 58.6 | 58.6 |
| Cedric Benson | CIN | 12 | 10 | 214 | 747 | 2 | 26 | 20 | 185 | 0 | 125.2 | 115.2 | 105.2 | 125.2 | 125.2 |
| Chester Taylor | MIN | 16 | 1 | 101 | 399 | 4 | 55 | 45 | 399 | 2 | 160.8 | 138.3 | 115.8 | 160.8 | 160.8 |
| Chris Johnson | TEN | 15 | 14 | 251 | 1228 | 9 | 62 | 43 | 260 | 1 | 251.8 | 230.3 | 208.8 | 251.8 | 251.8 |
| Chris Perry | CIN | 13 | 6 | 102 | 264 | 2 | 35 | 21 | 76 | 0 | 67 | 56.5 | 46 | 67 | 67 |
| Clinton Portis | WAS | 16 | 16 | 342 | 1487 | 9 | 36 | 28 | 218 | 0 | 252.5 | 238.5 | 224.5 | 252.5 | 252.5 |
| Correll Buckhalter | PHI | 14 | 2 | 76 | 369 | 2 | 32 | 26 | 324 | 2 | 119.3 | 106.3 | 93.3 | 119.3 | 119.3 |
| Darren McFadden | OAK | 13 | 5 | 113 | 499 | 4 | 38 | 29 | 285 | 0 | 131.4 | 116.9 | 102.4 | 131.4 | 131.4 |
| Darren Sproles | SD | 16 | 0 | 61 | 330 | 1 | 34 | 29 | 342 | 5 | 132.2 | 117.7 | 103.2 | 132.2 | 132.2 |
| DeAngelo Williams | CAR | 16 | 16 | 274 | 1518 | 18 | 30 | 22 | 121 | 2 | 305.9 | 294.9 | 283.9 | 305.9 | 305.9 |
| Derek Schouman | BUF | 16 | 12 | 0 | 0 | 0 | 20 | 15 | 153 | 1 | 36.3 | 28.8 | 21.3 | 36.3 | 36.3 |
| Derrick Ward | NYG | 16 | 3 | 182 | 1025 | 2 | 55 | 41 | 384 | 0 | 193.9 | 173.4 | 152.9 | 193.9 | 193.9 |
| DeShaun Foster | SF | 15 | 2 | 76 | 234 | 1 | 20 | 16 | 133 | 1 | 64.7 | 56.7 | 48.7 | 64.7 | 64.7 |
| DeShawn Wynn | GB | 5 | 0 | 8 | 110 | 1 | 3 | 3 | 30 | 0 | 23 | 21.5 | 20 | 23 | 23 |
| Deuce McAllister | NO | 13 | 6 | 107 | 418 | 5 | 22 | 18 | 128 | 1 | 108.6 | 99.6 | 90.6 | 108.6 | 108.6 |
| Dominic Rhodes | IND | 15 | 4 | 152 | 538 | 6 | 59 | 45 | 302 | 3 | 183 | 160.5 | 138 | 183 | 183 |
| Earnest Graham | TB | 10 | 10 | 132 | 563 | 4 | 33 | 23 | 174 | 0 | 120.7 | 109.2 | 97.7 | 120.7 | 120.7 |
| Edgerrin James | ARI | 13 | 7 | 133 | 514 | 3 | 18 | 12 | 85 | 0 | 89.9 | 83.9 | 77.9 | 89.9 | 89.9 |
| Felix Jones | DAL | 6 | 0 | 30 | 266 | 3 | 2 | 2 | 10 | 0 | 47.6 | 46.6 | 45.6 | 47.6 | 47.6 |
| Frank Gore | SF | 14 | 13 | 240 | 1036 | 6 | 66 | 43 | 373 | 2 | 231.9 | 210.4 | 188.9 | 231.9 | 231.9 |
| Fred Jackson | BUF | 16 | 3 | 129 | 560 | 3 | 45 | 37 | 317 | 0 | 142.7 | 124.2 | 105.7 | 142.7 | 142.7 |
| Fred Taylor | JAC | 13 | 13 | 143 | 556 | 1 | 22 | 16 | 98 | 0 | 87.4 | 79.4 | 71.4 | 87.4 | 87.4 |
| Gary Russell | PIT | 12 | 0 | 28 | 77 | 3 | 2 | 1 | -2 | 0 | 26.5 | 26 | 25.5 | 26.5 | 26.5 |
| Greg Jones | JAC | 12 | 8 | 2 | 13 | 0 | 14 | 13 | 116 | 1 | 31.9 | 25.4 | 18.9 | 31.9 | 31.9 |
| J.J. Arrington | ARI | 11 | 3 | 30 | 188 | 1 | 41 | 30 | 254 | 1 | 86.2 | 71.2 | 56.2 | 86.2 | 86.2 |
| Jacob Hester | SD | 16 | 4 | 19 | 95 | 1 | 13 | 12 | 91 | 1 | 42.6 | 36.6 | 30.6 | 42.6 | 42.6 |
| Jamaal Charles | KC | 16 | 2 | 67 | 357 | 0 | 40 | 27 | 272 | 1 | 95.9 | 82.4 | 68.9 | 95.9 | 95.9 |
| Jamal Lewis | CLE | 16 | 16 | 279 | 1002 | 4 | 32 | 23 | 178 | 0 | 165 | 153.5 | 142 | 165 | 165 |
| Jason McKie | CHI | 11 | 7 | 11 | 26 | 2 | 15 | 11 | 64 | 1 | 38 | 32.5 | 27 | 38 | 38 |
| Jason Snelling | ATL | 15 | 1 | 15 | 62 | 0 | 10 | 8 | 89 | 0 | 23.1 | 19.1 | 15.1 | 23.1 | 23.1 |
| Jason Wright | CLE | 15 | 0 | 23 | 85 | 0 | 37 | 22 | 156 | 1 | 52.1 | 41.1 | 30.1 | 52.1 | 52.1 |
| Jerious Norwood | ATL | 15 | 0 | 91 | 433 | 2 | 52 | 35 | 316 | 2 | 133.9 | 116.4 | 98.9 | 133.9 | 133.9 |
| Jerome Harrison | CLE | 15 | 0 | 34 | 246 | 1 | 18 | 12 | 116 | 1 | 60.2 | 54.2 | 48.2 | 60.2 | 60.2 |
| John Kuhn | GB | 16 | 3 | 8 | 10 | 1 | 8 | 4 | 21 | 2 | 25.1 | 23.1 | 21.1 | 25.1 | 25.1 |
| Jonathan Stewart | CAR | 16 | 0 | 183 | 835 | 10 | 17 | 8 | 47 | 0 | 156.2 | 152.2 | 148.2 | 156.2 | 156.2 |
| Joseph Addai | IND | 12 | 12 | 155 | 544 | 5 | 39 | 25 | 206 | 2 | 142 | 129.5 | 117 | 142 | 142 |
| Julius Jones | SEA | 15 | 10 | 158 | 698 | 2 | 25 | 14 | 66 | 0 | 102.4 | 95.4 | 88.4 | 102.4 | 102.4 |
| Justin Fargas | OAK | 14 | 14 | 219 | 855 | 1 | 15 | 10 | 52 | 0 | 106.7 | 101.7 | 96.7 | 106.7 | 106.7 |
| Kenneth Darby | STL | 9 | 1 | 29 | 120 | 0 | 19 | 17 | 174 | 0 | 46.4 | 37.9 | 29.4 | 46.4 | 46.4 |
| Kevin Faulk | NE | 15 | 3 | 83 | 507 | 3 | 74 | 58 | 486 | 3 | 193.3 | 164.3 | 135.3 | 193.3 | 193.3 |
| Kevin Smith | DET | 16 | 12 | 239 | 975 | 8 | 54 | 39 | 286 | 0 | 213.1 | 193.6 | 174.1 | 213.1 | 213.1 |
| Kolby Smith | KC | 7 | 3 | 35 | 100 | 1 | 11 | 10 | 52 | 0 | 31.2 | 26.2 | 21.2 | 31.2 | 31.2 |
| LaDainian Tomlinson | SD | 16 | 16 | 292 | 1110 | 11 | 77 | 52 | 421 | 1 | 277.1 | 251.1 | 225.1 | 277.1 | 277.1 |
| Ladell Betts | WAS | 13 | 0 | 61 | 206 | 1 | 35 | 22 | 200 | 0 | 68.6 | 57.6 | 46.6 | 68.6 | 68.6 |
| LaMont Jordan | NE | 8 | 0 | 80 | 363 | 4 | 0 | 0 | 0 | 0 | 60.3 | 60.3 | 60.3 | 60.3 | 60.3 |
| Larry Johnson | KC | 12 | 12 | 193 | 874 | 5 | 16 | 12 | 74 | 0 | 136.8 | 130.8 | 124.8 | 136.8 | 136.8 |
| Le'Ron McClain | BAL | 16 | 16 | 231 | 907 | 10 | 30 | 19 | 123 | 1 | 188 | 178.5 | 169 | 188 | 188 |
| LenDale White | TEN | 16 | 2 | 200 | 773 | 15 | 10 | 5 | 16 | 0 | 173.9 | 171.4 | 168.9 | 173.9 | 173.9 |
| Leon Washington | NYJ | 16 | 1 | 76 | 448 | 6 | 62 | 47 | 355 | 2 | 175.3 | 151.8 | 128.3 | 175.3 | 175.3 |
| Leonard Weaver | SEA | 14 | 7 | 30 | 130 | 0 | 32 | 20 | 222 | 2 | 67.2 | 57.2 | 47.2 | 67.2 | 67.2 |
| Marion Barber | DAL | 15 | 13 | 238 | 885 | 7 | 61 | 52 | 417 | 2 | 236.2 | 210.2 | 184.2 | 236.2 | 236.2 |
| Marshawn Lynch | BUF | 15 | 15 | 251 | 1047 | 8 | 67 | 47 | 300 | 1 | 235.7 | 212.2 | 188.7 | 235.7 | 235.7 |
| Matt Forte | CHI | 16 | 16 | 315 | 1231 | 8 | 77 | 64 | 484 | 4 | 307.5 | 275.5 | 243.5 | 307.5 | 307.5 |
| Maurice Jones-Drew | JAC | 16 | 3 | 197 | 824 | 12 | 75 | 62 | 565 | 2 | 284.9 | 253.9 | 222.9 | 284.9 | 284.9 |
| Maurice Morris | SEA | 13 | 6 | 132 | 574 | 0 | 27 | 19 | 136 | 2 | 102 | 92.5 | 83 | 102 | 102 |
| Mewelde Moore | PIT | 16 | 4 | 140 | 588 | 5 | 53 | 40 | 320 | 1 | 166.8 | 146.8 | 126.8 | 166.8 | 166.8 |
| Michael Bush | OAK | 14 | 0 | 94 | 419 | 3 | 30 | 19 | 162 | 0 | 95.1 | 85.6 | 76.1 | 95.1 | 95.1 |
| Michael Pittman | DEN | 8 | 3 | 76 | 321 | 4 | 14 | 10 | 112 | 0 | 77.3 | 72.3 | 67.3 | 77.3 | 77.3 |
| Michael Robinson | SF | 16 | 1 | 19 | 50 | 0 | 20 | 17 | 202 | 0 | 42.2 | 33.7 | 25.2 | 42.2 | 42.2 |
| Michael Turner | ATL | 16 | 16 | 377 | 1699 | 17 | 9 | 6 | 41 | 0 | 282 | 279 | 276 | 282 | 282 |
| Mike Sellers | WAS | 16 | 6 | 6 | 24 | 0 | 15 | 12 | 98 | 1 | 30.2 | 24.2 | 18.2 | 30.2 | 30.2 |
| Mike Tolbert | SD | 13 | 7 | 13 | 37 | 0 | 15 | 13 | 171 | 1 | 39.8 | 33.3 | 26.8 | 39.8 | 39.8 |
| Montell Owens | JAC | 16 | 0 | 2 | 43 | 2 | 3 | 2 | 17 | 0 | 20 | 19 | 18 | 20 | 20 |
| P.J. Pope | DEN | 5 | 1 | 17 | 130 | 0 | 4 | 3 | 24 | 1 | 24.4 | 22.9 | 21.4 | 24.4 | 24.4 |
| Patrick Cobbs | MIA | 16 | 2 | 12 | 88 | 1 | 27 | 19 | 275 | 2 | 73.3 | 63.8 | 54.3 | 73.3 | 73.3 |
| Peyton Hillis | DEN | 12 | 6 | 68 | 343 | 5 | 19 | 14 | 179 | 1 | 102.2 | 95.2 | 88.2 | 102.2 | 102.2 |
| Pierre Thomas | NO | 15 | 5 | 129 | 625 | 9 | 36 | 31 | 284 | 3 | 193.9 | 178.4 | 162.9 | 193.9 | 193.9 |
| Ray Rice | BAL | 13 | 4 | 107 | 454 | 0 | 43 | 33 | 273 | 0 | 105.7 | 89.2 | 72.7 | 105.7 | 105.7 |
| Reggie Bush | NO | 10 | 9 | 106 | 404 | 2 | 73 | 52 | 440 | 4 | 172.4 | 146.4 | 120.4 | 172.4 | 172.4 |
| Ricky Williams | MIA | 16 | 3 | 161 | 659 | 4 | 39 | 29 | 219 | 1 | 146.8 | 132.3 | 117.8 | 146.8 | 146.8 |
| Ronnie Brown | MIA | 16 | 13 | 214 | 916 | 10 | 43 | 33 | 254 | 0 | 210 | 193.5 | 177 | 210 | 210 |
| Rudi Johnson | DET | 14 | 4 | 76 | 237 | 1 | 14 | 12 | 88 | 1 | 56.5 | 50.5 | 44.5 | 56.5 | 56.5 |
| Ryan Grant | GB | 16 | 14 | 312 | 1203 | 4 | 19 | 18 | 116 | 1 | 179.9 | 170.9 | 161.9 | 179.9 | 179.9 |
| Ryan Moats | HOU | 8 | 0 | 26 | 94 | 1 | 5 | 3 | 14 | 0 | 19.8 | 18.3 | 16.8 | 19.8 | 19.8 |
| Sammy Morris | NE | 13 | 7 | 156 | 727 | 7 | 24 | 17 | 161 | 0 | 147.8 | 139.3 | 130.8 | 147.8 | 147.8 |
| Selvin Young | DEN | 8 | 5 | 61 | 303 | 1 | 8 | 3 | 16 | 0 | 40.9 | 39.4 | 37.9 | 40.9 | 40.9 |
| Steve Slaton | HOU | 16 | 15 | 268 | 1282 | 9 | 59 | 50 | 377 | 1 | 275.9 | 250.9 | 225.9 | 275.9 | 275.9 |
| Steven Jackson | STL | 12 | 11 | 254 | 1043 | 7 | 62 | 40 | 379 | 1 | 230.2 | 210.2 | 190.2 | 230.2 | 230.2 |
| T.J. Duckett | SEA | 16 | 0 | 62 | 172 | 8 | 0 | 0 | 0 | 0 | 65.2 | 65.2 | 65.2 | 65.2 | 65.2 |
| Tashard Choice | DAL | 16 | 3 | 92 | 472 | 2 | 30 | 21 | 185 | 0 | 98.7 | 88.2 | 77.7 | 98.7 | 98.7 |
| Tatum Bell | DEN | 7 | 3 | 44 | 249 | 2 | 14 | 10 | 57 | 0 | 52.6 | 47.6 | 42.6 | 52.6 | 52.6 |
| Thomas Jones | NYJ | 16 | 14 | 290 | 1312 | 13 | 42 | 36 | 207 | 2 | 277.9 | 259.9 | 241.9 | 277.9 | 277.9 |
| Tim Hightower | ARI | 16 | 7 | 143 | 399 | 10 | 49 | 33 | 230 | 0 | 155.9 | 139.4 | 122.9 | 155.9 | 155.9 |
| Vonta Leach | HOU | 16 | 12 | 1 | 1 | 1 | 18 | 12 | 103 | 0 | 28.4 | 22.4 | 16.4 | 28.4 | 28.4 |
| Warrick Dunn | TB | 15 | 6 | 186 | 786 | 2 | 68 | 47 | 330 | 0 | 170.6 | 147.1 | 123.6 | 170.6 | 170.6 |
| Willie Parker | PIT | 11 | 11 | 209 | 789 | 5 | 11 | 4 | 15 | 0 | 114.4 | 112.4 | 110.4 | 114.4 | 114.4 |
| Willis McGahee | BAL | 14 | 8 | 170 | 671 | 7 | 32 | 24 | 173 | 0 | 150.4 | 138.4 | 126.4 | 150.4 | 150.4 |